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Larger-scale, multi-center, placebo-controlled RCTs with important and conclusive outcome, for example PSE index, number of patients with improved clinical syndrome, are expected to identify the role of ALC therapy in HE

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Y ah es donde debemos fijarnos , advierte Juana Carretero , mdico internista del Hospital Universitario de Badajoz y miembro del Grupo de Diabetes, Obesidad y Nutricin de la Sociedad Espaola de Medicina Interna (SEMI)

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Because GH release and downstream markers are regulated by feedback mechanisms, combination studies often emphasize time-course design, signaling endpoints, and reproducibility of assay conditions