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As a self-insured employer, they saw how quickly costs added up: more than $25 million a year for fewer than 5% of employees

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It's particularly warranted if mood symptoms are accompanied by neurological signs (numbness, tingling, balance issues) or anemia symptoms (fatigue, pallor, shortness of breath)

Slow dose escalation also reduces fatigue intensity compared to rapid titration

Collagen type II is different in that it primarily affects cartilage

Manufacturers took note, and began to tune them for weight-loss and convenience