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Patients with pre-existing diabetic retinopathy should be monitored closely, as rapid improvement in blood glucose control may temporarily worsen retinopathy

N Engl J Med (2021) 384:9891002

This binding activates adenylate cyclase, leading to elevation of cAMP and PKA, which finally enhances insulin biosynthesis and secretion, and suppressed glucagon secretion [4]

From these conversations, the idea of combining the two medications (semaglutide and tirzepatide), but at lower individualized doses, was born

GLP-1 drugs like Ozempic and Wegovy are groundbreaking treatments for type 2 diabetes and obesity

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