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Prez-Revuelta BI et al

Ophiopogonin B induces gastric cancer cell death by blocking the GPX4/xCT-dependent ferroptosis pathway

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Other mechanisms that regulate the intracellular iron abundance, such as the exportation of iron via various multivesicular bodies and exosomes carrying ferroportin or prominin2-mediated ferritin, can also affect the cellular sensitivity to ferroptosis, as they deplete the cellular iron and accelerate the lipid peroxidation (53) ( Figure 1 )

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10.1096/fj.201901120R FASEB J