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10.1007/s00395-015-0497-2 26 LiR.LiuY.ShanY

They cause massive reductions in metabolic rate, break down muscle (which is also important for normal metabolic function), and are almost never effective long-term

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It inhibits tyrosinase (the key enzyme that makes dark melanin) and shifts pigment synthesis toward lighter pheomelanin

The post says the prescribing provider's monitoring is the strongest safety lever, ahead of the compounding pathway itself

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