Patients may also experience some mild side effects, such as nausea, gastrointestinal symptoms like diarrhea or constipation, and headaches
These arguments are largely based on rodent studies, which have found that prolonged fasting can reduce serum IGF-1 by up to 40% (18)
Fraser A, Harris R, Sattar N, Ebrahim S, Smith GD, Lawlor DA
That data wasn't always included in the FDA scientists' presentations a decision that rankled some committee members
Furthermore, patients with advanced PD are at risk of developing dementia as a result of the accumulation of -Syn in Lewy bodies
As a result, high-quality RWD and RWE are expected to play an increasingly important role throughout the product lifecycle, supporting reimbursement, market access, and post-launch evidence generation