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13, 20, 26, 27, 48, 70, 71, 72 They are actively taken up into the brain 73 and can affect diverse physiological processes such as cell signaling, 71 neurotransmitter synthesis and release, 70 mitochondrial function, 20 lipid metabolism, 13, 74 immune function, 75 cellcell interactions 76 and gene expression

MOTS-c interacts synergistically with exercise intervention to regulate PGC-1 expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway

L.KorkinaO.TengX.et al (2008)

Abdominal bloating decreases (partly from visceral fat reduction, partly from reduced inflammation in adipose tissue)

In the present study, we clearly demonstrated that long-term HFD consumption decreased hepatic NF-B activity

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