Where the Community Theory Goes Beyond the Research The "copper uglies" theory extends the documented MMP mechanism into a specific claim: that in ordinary use on intact skin, this remodelling activity can temporarily outpace new collagen synthesis, producing a visible dip in skin appearance before things improve
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Cold Spring Harbor Perspectives in Biology., 12 (1), a038802
The reconstitution math is similar, but KLOW adds KPV as a fourth anti-inflammatory peptide that GLOW does not contain
Mol Cell Biochem 286:95101, PMID: 16583144 Halliwell B, Gutteridge JMC (1989) Free radicals in biology and medicine
So, treating the initial B12 deficiency is a little bit more labor intensive if you like