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At 15 C, we observed similar results where glp-1(-) and fem-3(-) mutants lived longer and mog-3(-) mutants lived shorter than WT, although all strains had a longer lifespan at 15 C compared to 25 C, as expected (Supplementary Fig
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233 In one large observational study that followed nearly 500,000 participants for about 11 years, drinking up to 34 cups per day of any type of coffee, including decaffeinated, instant, or ground coffee, was associated with lower risks of all types of chronic liver disease, including NAFLD, as well as cirrhosis and hepatocellular cancer
Tirzepatide at its starting dose of 2.5mg may take longer to produce noticeable appetite effects because this dose is primarily intended for tolerability rather than efficacy
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