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Head Face Med 2014;10:8.DOI: 10.1186/1746-160x-10-8
The DAC (drug affinity complex) conjugation extends half-life from 30 minutes to 68 days, which is what makes twice-weekly dosing viable
Despite the fact that IGF-1 LR3 is an analog with 2-3 times higher potency and purportedly longer half-life, it is unlikely that taking it in doses more than ten times lower than insulin-like growth factor 1 may provide any noticeable effects
HIF-1 is upregulated in various human cancers and plays a key role in driving tumor growth, invasion and metastasis
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