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41 The significant reduction in urinary oxalate excretion after weight loss through GLP-based therapies could possibly be attributed to decreased intake of oxalate and oxalate precursors or to reduced hepatic oxalate synthesis

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While the structural basis of GLP-1R biased agonism between arrestin recruitment and G protein pathways is still not clear and will require additional studies to decipher, there is growing evidence that biased agonism is associated with the conformation and dynamics of the TM6/ECL3/TM7/TM1 domain 3,14,16,27,29 , and this is consistent with the data presented herein

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With physician oversight, thoughtful dose management, and personalized symptom support, most patients achieve steady progress with minimal discomfort