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509 Clinical evidence indicates that the expression of ER stress-related proteins such as IRE1, PERK, and CHOP is reduced in SLE patients, while the levels of XBP1 and midbrain astrocyte-derived neurotrophic factor (MANF) are elevated, suggesting their potential role in disease development

Yu S, Bruce D, Froicu M, Weaver V, Cantorna MT

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The peptide reduced COX-2 gene expression and myeloperoxidase activity in various inflammation models[11]

It is formulated to: Reduce the appearance of dark spots, hyperpigmentation, and uneven skin tone