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270 More importantly, p53 is regulated only in AgRP neurons and not in major neuronal populations of the arcuate nucleus of the hypothalamus (ARC), which suggests that p53 alterations associated with energy balance are nucleus-specific

Published preclinical studies used intraperitoneal injection in rodents, which bypasses the subcutaneous absorption variability human protocols face

If treatment with N-acetylcysteine causes resolution of the acidosis, this supports the diagnosis

Type 2 APS is defined by the occurrence of Addison's disease with thyroid autoimmune disease and/or Type 1 diabetes mellitus

14 kDa), also biologically active 6,7

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