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The combination of BSO+L-PAM achieved synergistic cytotoxicity (combination index number (CIN) 0.7) and induced 24 logs of cell kill in all nine MM cell lines including the eight lines established at progressive disease (PD) after therapy (U266, OPM-2, NCI H929, KMS-12-PE, EJM, TX-MM-030h, MM.1S and MOLP-2), 25 which include lines with cytogenetic profiles associated with a poor prognosis (Figure 1b)

Despite these promising insights, several limitations remain in current research

10.1016/j.ejphar.2020.173473 149 ShimadaK.SkoutaR.KaplanA.YangW

Cleaning: Thoroughly clean and rinse all equipment after each use