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Since erythrocytes make up approximately 99% of the blood cells (24), this cell population has the greatest impact on hematocrit and is closely correlated with it in the present study (r = 0.82)

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Multiple mechanisms drive pathological ROS accumulation in diabetic cardiomyocytes, such as inhibition of mitochondrial oxidative phosphorylation elevating O 2 production, activation of NOX by angiotensin II (Ang II) and TNF-, and AGEs-RAGE binding-induced NF-B activation that triggers inflammation and further ROS generation