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The practice dates back to the early 1990s, when it was used to safely study how newly developed drugs are absorbed, metabolized, and eliminated by the body

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10.1007/s00395-015-0476-7 55 SampedroJ.BogdanovP.RamosH.Sol-AdellC.TurchM.ValeriM.et al (2019)

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Conditions such as heart disease, chronic kidney disease, and obstructive sleep apnea may affect which GLP-1 medication is chosen for treatment

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