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Certainly, a greater number of type II muscle fibers are shown in resistance and sprint-trained individuals while muscle carnosine has a higher content in type II glycolytic fibers compared to type I oxidative fibers (65)

The data reported by Liou et al

And more importantly, we know how to fix it

SOURCE: New England Journal of Medicine , April 4, 2024

96,97 Moreover, the ME1 protein is hypophosphorylated at S336 and hyperacetylated at K337 by PGAM family member 5 and acetyl-CoA acetyltransferase, respectively, resulting in ME1 translocation from mitochondria to the cytosol, dimerization and activation, thus strongly promoting NADPH generation and tumorigenesis

206 (Supplement 3) JU.0000000000001982