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The distinction between adaptive and maladaptive muscle loss is central to understanding the quality, not just the quantity, of BW loss achieved with GLP-1 RA-based therapies [37, 38]

MASLD was evaluated applying the (NAFLD) activity score (NAS), by allocating points for histological findings of steatosis, hepatocyte ballooning and inflammation activity 48

In the published trials, around a quarter of total weight loss has come from lean tissue

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

Inconsistent product availability is another warning sign worth tracking

However, adherence remains a challenge