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Am J Physiol Regul Integr Comp Physiol 2012;302:R751-R767
Detailed information on the GLP-1 medication dose, duration, and patient adherence was not available for all study participants who came from a single integrated health system, thus possibly making it difficult to generalize for the broader population
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Mitigating Metabolic Adaptation Rapid weight loss invariably leads to "metabolic adaptation" or adaptive thermogenesisa disproportionate reduction in Resting Energy Expenditure (REE) that fights against further weight loss