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This discovery not only advances existing research on how Tirzepatide acts in diabetes and its related complications, but also provides novel theoretical underpinnings for future interventions combining targeted gut microbiota manipulation with pharmacological treatments

In this study, we firstly confirmed that compared with RBITC-GLP-1RAs@NPs, RBITC-GLP-1RAs@NPs-WYRGRL could effectively target tissues with abundant cartilage, such as joints, and could be retained in cartilage tissues more effectively, and thus be excreted by the kidneys less

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Usually injected in the abdomen, thigh, or upper arm

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