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Hyperglycemia has been shown to negatively regulate FoxO1 expression and paralleled loss of insulin content 22

282,283 These cells accumulate in the synovial membrane and subchondral bone, releasing pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which promote the degradation of joint cartilage and the inflammatory response

"Insulin requirements are often lower in individuals with type 1 using a GLP-1 receptor agonist," said Dr

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