These drugs mimic the action of naturally occurring GLP-1, a hormone released by the intestine in response to food intake
12 Place in Therapy The American Association of Clinical Endocrinologists (AACE) and American College of Endocrinology (ACE) developed an algorithm to assist providers in managing type 2 diabetes
The mechanism is distinct from older weight-loss drugs because GLP-1 agonists mimic a hormone your body produces naturally after eating
Pharmacologically mediated, marked initial maternal body weight loss and reductions in body weight gain and food consumption coincided with the occurrence of sporadic abnormalities (vertebra, sternebra, ribs) at 0.075 mg/kg twice weekly (3X human exposure)
Hum Mutat 35(12):14491458 Forny P et al (2023) Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency
Because the transient nature of endogenous GLP-1 is insufficient to override the intracellular resistance seen in chronic disease, pharmacological innovation has focused on engineering molecules that can sustain the receptors protective signalosomes over extended periods ( Figure 1 , right)
