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The mechanism work on this is active: GLP-1R is expressed in cardiovascular tissue, and receptor activation there appears to modulate inflammation, endothelial function, and possibly plaque biology through pathways that are not obviously downstream of insulin or appetite regulation

In addition, a multicenter, randomized controlled trial in patients with T2DM without cardiovascular disease also found that the mean carotid intimal thickness and left carotid intimal thickness after sitagliptin treatment were significantly reduced from baseline, with no significant difference on the right side

What Are GLP-1 RAs

Increased weight reduction with tirzepatide treatment has been reported to be associated with greater improvement in physical function [59]

Am J Ophthalmol 2025;274:24-31.ArticlePubMed 100

doi:10.1016/j.obpill.2025.100228