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Head-to-head trials will be needed

The bottom line Newer GLP-1-based drugs can lead to powerful benefits for blood sugar, weight, and heart health, but nausea can make treatment unpleasant especially during the first few weeks of treatment or shortly after increasing the dose

That said, adopting lifestyle strategies while taking a GLP-1 might help to reduce the risk of regain

Starting at a low dose and increasing it gradually may help reduce gastrointestinal side effects

We found that GLP-1RAs were associated with a reduced risk of intestinal obstruction compared to insulin

Conclusion GLP-1 medications present cost challenges, with monthly expenses often exceeding $1,000 monthly without insurance coverage