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In the present study, we examined Trp and its metabolites, Kyn, KYNA, and 5-HT, since the associated metabolic pathways produce several neuroactive substances [35], [36]

FUNDING The author(s) received no financial support for the research, authorship, and/or publication of this article

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This, along with environmental exposure to things like pollution and UV rays, lead to noticeable signs of aging

Unlike fine lines that may improve quickly, established expression lines need time for accumulated collagen to fill in grooved skin and for improved elasticity to prevent further deepening

reduced the activation of caspases associated with the intrinsic apoptotic pathway, suppressed mitochondrial cytochrome C release, and decreased UVB-induced DNA fragmentation (Sisto et al., 2012)