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However, that study was done in only 6 subjects, raising concerns about the lack of statistical power to detect a clinically relevant effect

Case reports suggest dehydration and orthostatic symptoms increase in hot months

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38 GLP-1RAs increase microvascular blood flow in muscle tissue, enhance myocyte metabolism, inhibit muscle atrophy, and improve muscle mass and function

In terms of renal effects, the evidence of SGLT2is in preventing kidney failure is more abundant than for GLP-1RAs, which showed a beneficial effect on albuminuria and not on hard kidney endpoints [3, 6, 8]

Metabolism 49 , 709717 (2000)