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Targeting ferroptosis opens new avenues for the development of novel therapeutics

doi: 10.3390/cancers11040505

High NAD + level occurs in fasting and has been associated with health outcomes in model systems, while low NAD + /NADH ratio occurs in specific diseases

The median total dose (including all administrations from pre-surgical PK and loading doses to post-hospital follow up) was 629 IU/kg (range: 464 1,457 IU/kg) for major orthopedic surgeries, 489 IU/kg (range: 296 738 IU/kg) for major non-orthopedic surgeries