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Furthermore, studies found that LPS-induced macrophages in patients can release HMGB1 via extracellular vesicles (EVs), subsequently activating the NLRP3 inflammasome to trigger hepatocyte pyroptosis [46]

therefore, LAT1 ( SLC7A5 ) is essential for maintaining the intracellular SAM concentration

PubMed Central , Neuropharmacology , vol

Moreover, the expression levels of genes were compared with those of the control group using Dunnetts test (GraphPad Prism version 9.5, GraphPad Software, La Jolla, CA)

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Traditionally, in PCOS, one of the main aspects to consider is hyperglycemia, as it can trigger type 2 diabetes mellitus, cardiovascular diseases, the production of inflam-matory factors, and reactive oxygen species that cause oxidative stress and tissue damage 5