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TRIUMPH-1 (NCT05929066), the Phase 3 registration trial for the obesity indication, reported topline results on May 21, 2026 : average weight loss of 28.3% at 80 weeks at the highest dose in 2,339 participants, versus 2.2% on placebo, and 30.3% at 104 weeks among participants with a BMI of 35 or above who continued in a pre-specified extension

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Clin Sports Med

Stress can influence hormones and inflammation

The medication works synergistically with lifestyle modifications rather than replacing them entirely

Semenova G, Stepanova DS, Deyev SM, Chernoff J