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c Testing binding of structure-based BRD4 BD1 mutants to fluorescent FAM-JQ1 probe with a fluorescence polarization assay (SD, n = 3)

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PMID 11311052

143,144 The mutated IDH1 and IDH2 proteins are endowed with a novel ability to catalyze the reduction of -KG to generate a rare metabolite, 2-hydroxyglutarate (2-HG), while consuming NADPH