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Following surgery, the patient initially presented with persistent hypesthesia of the right arm, distal weakness of the left arm with a muscle strength grade of 4/5, and proximal weakness of the right arm with a strength grade of 3/5

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Overall, a single administration of in vivo genome editing-mediated scExe4 knock-in provides stable, long-term metabolic benefits, effectively restoring blood glucose homeostasis and preventing relapse of pre-diabetic symptoms in non-genetic DIO mice

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