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The amount of oral intake needed to achieve gastric and intestinal fullness and signal satiety to the brain through the gut-brain axis can overwhelm the evolutionarily determined metabolic capacity of peripheral organs such as liver, pancreas, fat tissue, and muscles

Lancet 2 , 13001304 (1987)

Neilson, the Lewis Landsberg Dean and Vice President for Medical Affairs

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Diarrhea, vomiting, constipation, abdominal pain, and decreased appetite also occur in a meaningful minority of patients on both drugs

IBS and GLP-1: What the Clinical Evidence Shows Recent data suggests that GLP-1 therapy does not worsen IBS in most patients when dosing is managed carefully