Activation of CPT1 by L-carnitine facilitates the conversion of L-carnitine and acyl-CoA into acylcarnitine, thereby modulating fatty acid metabolism [55, 56]
Modulation of the permeability transition pore Studies have reported that mitochondria permeabilize due to the mitochondrial permeability transition pore (mPTP) opening, a pathophysiological event that, under favorable conditions, causes an increase in permeability of the inner mitochondrial membrane and leads to mitochondrial depolarization, swelling, and the activation of the apoptotic and necrotic pathways 43
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