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3.6 Evaluation of cytokines modulation during wound healing in vitro model To parallel the in vivo analyses, soluble mediator levels were measured in supernatants from HCEpiC scratch-wound assays treated with HA + GSH-C4 or HA-only, under basal conditions and following LPS- or H 2 O 2 -induced stress (Supplementary Figure S1)

Due to these nutritional transitions, undernutrition coexisting with overnutrition is widely prevalent in many parts of the world [1], with estimates that micronutrient deficiencies affect more than 2 billion people globally [2]

H3R antagonists such as ciproxifan have also been effective in enhancing alertness and memory [60], alleviating repetitive behavior in VPA-exposed mice [62], and correcting aberrant histamine-modulated neural activity in the cortico-basal ganglia circuitry [63,64] (Figure 1)

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