Across both trials, the side-effect profile matched what had been seen in prior retatrutide research, with gastrointestinal complaints chiefly diarrhea, nausea, and constipation topping the list, as is typical for GLP-1 medications, the company said
5-fold weaker affinity than native GLP-1)
In addition, our approach is constrained by the limited number of genetic proxies available to GLP-1RAs, which would preclude further sensitivity analyses for horizontal pleiotropy [39]
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The final approved doses and labeling will be determined by the FDA
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