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Then, in 2015, Lee and colleagues identified a previously overlooked open reading frame within the 12S ribosomal RNA gene of mtDNA and found that it encodes a functional peptide, MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) [1]

Technique : The needle is inserted at a 45-degree angle to the skin

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Think of your skin like a balloon - if you take out the air, that balloon will sag downward

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