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Low urinary pH predisposes for uric acid precipitation since the pKa of uric acid is 5.7, therefore the solubility of uric acid decreases with low pH, and thus increasing the risk of kidney stones ( Hypercalciuria has also been documented following keto-induction, with some studies documenting a 60% increase in excreted calcium, which could increase the risk of precipitation and developing kidney stones (73)

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Therefore, circVANGL1 is believed to act as a tumor promoter through IGFBP-2 upregulation [45] (Fig

No significant difference was observed in the expression of GSR ( P = 0.3)

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