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To mitigate any potential negative effects on methylation, additional interventions can support the methyl cycle while using folinic acid therapy: Improving SAH (S-adenosylhomocysteine) levels by reducing homocysteine through methyl donors like betaine (TMG), vitamin B6 (P5P), and methylcobalamin (B12)

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Nonenzymatically modified mRNA for regulating translation and apoptosis by modulating cancer epigenetics

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HX: conceptualization, methodology, supervision, and writingreview and editing