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Homocysteine levels should also be checked, as methionine supplementation can raise homocysteine if B12 or folate status is inadequate

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16 Macrophages and lymphocytes in the ovarian tissue of PCOS patients secrete large amounts of TNF- and IL-6, resulting in inhibition of the formation of dominant follicles and apoptosis of granulosa cells

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For a medication that requires refrigeration, this raises legitimate potency questions

Its primary biological function is the stimulation of insulin secretion in a glucose-dependent manner while simultaneously suppressing glucagon release