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Doses of vitamin B12 exceeding 10 mcg daily may produce hematologic response in patients with folate deficient megaloblastic anemia and may therefore mask a previously unrecognized folate deficiency

Notes that high-dose niacin passes into breast milk and that lipid-altering doses could pose risks to nursing infants, recommending caution or avoidance of such doses during breastfeeding)

Vitamin B12 shots are administered most often in those with genetic conditions that block absorption and people with the disorder called pernicious anemia, which can result in severe malabsorption and deficiency

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