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In the pre-marketing PIONEER-6 trial, a similar reduction in MACE rates was observed for oral semaglutide versus placebo, though statistical significance was not reached due to smaller event numbers than in SUSTAIN-6 [8]

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Third, the dipeptide cysteinylglycine (CysGly) which is an intermediate breakdown product of GSH was tested although its relative import rate as compared to other cysteine-containing derivatives is unknown