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doi: 10.1016/j.bcp.2017.07.010

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While the level of evidence for each compound varies, all of them lack the kind of large, well-controlled trials in humans that are necessary to establish safety and effectiveness, which is required for drug approvals

12 A separate study of people with T2D treated with GLP-1s found the rate of suicide attempts was more than 53% lower in the GLP-1 group compared to patients treated with DPP-4 inhibitors (oral hypoglycemics)