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When it was found that foods containing NAD+ precursors, particularly vitamin B3, may treat the fatal illness pellagra, which is characterized by diarrhea, dermatitis, dementia, and death, the clinical significance of maintaining NAD+ levels was established in the early 1900s

indole has a role too in the maintenance of the gut health [38]

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The imbalance of the antioxidant defense system may lead to autoimmune, neurological, endocrine, and oxidative stress issues (51)