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The most frequently used treatment relies on the combination of several immunosuppressants such as corticosteroids, leflunomide, and standard disease-modifying antirheumatic drugs (DMARDs) like methotrexate (MTX) 11 to address joint inflammation

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Senescent cancer cell vaccines induce cytotoxic T cell responses targeting primary tumors and disseminated tumor cells

141,146,147 Glutamine metabolism Glutamine metabolism is a major cellular carbon source for the TCA cycle, a nitrogen donor for nucleotide, amino acid, and lipid biosynthesis, it is also critical for maintaining NADPH levels