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Moderate-risk patients benefit from enhanced fasting protocols and consideration of gastric ultrasound assessment [56]

C-reactive protein and inflammatory markers indicate whether systemic inflammation is impairing L-cell function and nutrient sensing

Documented symptomatic hypoglycemia (glucose of 70 mg/dL or less) was reported in 16.7% to 29.8% of patients receiving semaglutide, and severe or blood glucose confirmed symptomatic hypoglycemia (glucose of 56 mg/dL or less) was reported in 8.3% to 10.7% of patients receiving semaglutide

Clin Endocrinol 2005;63:280-93

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While individually beneficial, research has shown that the combination creates enhanced effects on blood flow / vasodilation, nitric oxide production, and body composition better than either ingredient can achieve alone