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This generated a baseline, complication-free utility value that varied with BMI across cycles, consistent with prior obesity economic models (2124)

Most GLP-1 drugs used for weight loss, such as Mounjaro and Zepbound as well as Novo Nordisk 's Ozempic and Wegovy, are administered by injection

That means the worsening on re-escalation is tangled up with drug accumulation and cannot be put down to the dose increase alone, which softens the rechallenge-dependent Naranjo items and the dose-dependence story along with them

Viking's chief executive, Brian Lin, said that "the progressive nature of the weight loss curves suggests the potential for further improvement with longer dosing periods," suggesting that VK2375 could still mount a challenge to rival oral therapies, which have been tested over longer periods of a year or more

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PubMed Central , Journal of Biological Chemistry , vol