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Observed side effects in research settings are generally mild and may include temporary nausea-related observations, flushing-related observations, headache-related observations, fatigue-related observations, administration-site irritation, pigmentation variability, pigmentation variability involving freckles or moles, and temporary appetite-related response variability depending on research amount, UV exposure, administration frequency, skin type, and individual physiological sensitivity

[18] MS patients experiencing worsening neurological symptoms during semaglutide therapy require prompt evaluation to distinguish medication effects from MS disease activity, though the latter is far more likely

All three of the patients had been taking the drug for obesity and had managed to lose between 23 and 57 percent of their body weight thanks to the treatment

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