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GHK-Cu: The Copper Peptide That Rewires Gene Expression for Tissue Repair GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring tripeptide first isolated in 1973 by biochemist Loren Pickart, who observed that plasma from younger individuals stimulated regenerative processes more effectively than plasma from older adults.21 Tracing this activity to a small copper-binding peptide, Pickart launched over five decades of research into a molecule with an unusually broad biological profile: it stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, and supports dermal fibroblast function.22 The Gene-Expression Story What distinguishes GHK-Cu is the scale of its gene-regulatory effects