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A formal mediation analysis in SELECT estimated that waist circumference reduction accounted for no more than 33% of the MACE effect

Stofanko M, Kwon SY, Badenhorst P

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Elevated ROS activate FoxO-, NF-B-, and MAPK-dependent catabolic pathways, stimulate ubiquitinproteasome and autophagylysosome systems, and suppress PI3K/Akt/mTOR-mediated anabolic signaling

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