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Provenance and peer review: Not commissioned, externally peer reviewed

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Provider lead and formulation are matched to which group your case falls into

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For studies that reported the number of individual side effects but not the number of patients experiencing a side effect, this probability was determined using maximum likelihood estimation under a binomial model

First, these studies assessed structurally distinct compounds profiled in different enzymatic assays in vitro and separate groups of animals in vivo, and we do not have external validation of the relative toxicities of the various compounds studied in independent laboratories